All Articles

Sugar and Dementia: A Deep Dive (Webinar with Dr. Richard Johnson follow-up + recording)

Video
August 19, 2022
By
Ehab Naim, MBA.

We are delighted to announce a successful webinar in collaboration with Dr. Richard J. Johnson, a globally renowned expert in research on sugar and its role in health and longevity.

We are delighted to announce a successful webinar in collaboration with Dr. Richard J. Johnson, a globally renowned expert in research on sugar and its role in health and longevity. In the webinar, he discussed how fructose intake could initiate a survival switch, explained the connection between sugar and dementia, and described food types that can lead to neuron loss. We bring you the most interesting points from the webinar in this article. Read on to learn more. Dr. Richard J. Johnsonis a practicing physician and leading clinical scientist in the field of the connection between sugar and health. He is a Professor of Medicine at the University of Colorado in Denver. The webinar was hosted by HealthyLongevity.guide Content Manager Agnieszka Szmitkowska, Ph.D.


Animals regulate their weight

At the beginning of the webinar, Dr. Johnson highlighted that increased sugar intake had been associated with obesity and insulin resistance. Using rats as an example, he mentioned that most animals regulate their weight to have a little excess fat for emergencies. Then, Dr. Johnson explained how some animals, like bears, develop metabolic syndrome while preparing for hibernation. He explained the features that these animals develop, including:

  • Increased food and water intake (foraging, hunger)
  • Reduced resting metabolism
  • Elevated serum, liver, and tissue fat
  • Insulin resistance
  • Mild inflammation

What is the role of fructose?

Later, Dr. Johnson highlighted that some animals increase their fruit intake to boost their fat stores and mentioned that the primary nutrient in fruits is fructose. Fructose plays a role as a survival switch and improves the body's ability to fight infection, reduces oxygen and energy needs, and conserves body functions, among others. Dr. Richard pointed out the pathway involved in survival switch activation through the activity of ketohexokinase. He clarified that the polyol pathway could also produce fructose inside the body.

Is there a connection between the survival switch and Alzheimer’s?

Dr. Johnson provided an overview of Alzheimer’s disease (AD) and explained the possible connection between the survival pathway and conditions like dementia. He highlighted the overactivation of the survival switch as a potential driver for dementia. He further pointed out that this is possibly attributed to the similarities between the risk factors responsible for AD and switch activation.

Fructose might cause dementia

He then discussed how fructose could cause dementia and revealed that it all starts with the foraging response. Fructose causes hunger and desire for food and reduces willpower and recent memory. Dr. Richard then highlighted uric acid as a driver for foraging responses and AD and delved deeper into the impact of fructose on the brain, AD, and dementia.

These foods might lead to neuron loss

Towards the end of the presentation, Dr. Richard mentioned foods that activate the survival switch, which controls obesity that is driven by fructose. Examples of these foods include:

  • Sugar
  • High-fructose corn syrup
  • High glycemic carbohydrates (bread, rice, and potatoes)
  • Salty foods (french fries and potato chips)
  • Processed meats

Finally, he mentioned that evidence suggests that high intake of the abovementioned foods may increase brain fructose levels, initiating a foraging response, followed by persistent “hyperactive foraging”, then neuron loss and death.

To know more, watch the full webinar

Be sure to check the recording of this webinar by visiting the HealthyLongevity.guide, where you can find much more information you can utilize to improve the longevity of your clients.

Don’t miss this book by Dr. Richard Johnson

In the marketplace section, you can find Dr. Johnson's publication ‘Nature Wants Us to Be Fat: The Surprising Science Behind Why We Gain Weight and How We Can Prevent—and Reverse—It’.

What’s next?

Stay tuned for our next webinar with Natasa Billeci on November 10, 9 AM PT. The upcoming webinar will cover the topic of “Reproductive Longevity: The Key to Women's Healthspan”.

Some useful sources

 

 

We are delighted to announce a successful webinar in collaboration with Dr. Richard J. Johnson, a globally renowned expert in research on sugar and its role in health and longevity. In the webinar, he discussed how fructose intake could initiate a survival switch, explained the connection between sugar and dementia, and described food types that can lead to neuron loss. We bring you the most interesting points from the webinar in this article. Read on to learn more. Dr. Richard J. Johnsonis a practicing physician and leading clinical scientist in the field of the connection between sugar and health. He is a Professor of Medicine at the University of Colorado in Denver. The webinar was hosted by HealthyLongevity.guide Content Manager Agnieszka Szmitkowska, Ph.D.


Animals regulate their weight

At the beginning of the webinar, Dr. Johnson highlighted that increased sugar intake had been associated with obesity and insulin resistance. Using rats as an example, he mentioned that most animals regulate their weight to have a little excess fat for emergencies. Then, Dr. Johnson explained how some animals, like bears, develop metabolic syndrome while preparing for hibernation. He explained the features that these animals develop, including:

  • Increased food and water intake (foraging, hunger)
  • Reduced resting metabolism
  • Elevated serum, liver, and tissue fat
  • Insulin resistance
  • Mild inflammation

What is the role of fructose?

Later, Dr. Johnson highlighted that some animals increase their fruit intake to boost their fat stores and mentioned that the primary nutrient in fruits is fructose. Fructose plays a role as a survival switch and improves the body's ability to fight infection, reduces oxygen and energy needs, and conserves body functions, among others. Dr. Richard pointed out the pathway involved in survival switch activation through the activity of ketohexokinase. He clarified that the polyol pathway could also produce fructose inside the body.

Is there a connection between the survival switch and Alzheimer’s?

Dr. Johnson provided an overview of Alzheimer’s disease (AD) and explained the possible connection between the survival pathway and conditions like dementia. He highlighted the overactivation of the survival switch as a potential driver for dementia. He further pointed out that this is possibly attributed to the similarities between the risk factors responsible for AD and switch activation.

Fructose might cause dementia

He then discussed how fructose could cause dementia and revealed that it all starts with the foraging response. Fructose causes hunger and desire for food and reduces willpower and recent memory. Dr. Richard then highlighted uric acid as a driver for foraging responses and AD and delved deeper into the impact of fructose on the brain, AD, and dementia.

These foods might lead to neuron loss

Towards the end of the presentation, Dr. Richard mentioned foods that activate the survival switch, which controls obesity that is driven by fructose. Examples of these foods include:

  • Sugar
  • High-fructose corn syrup
  • High glycemic carbohydrates (bread, rice, and potatoes)
  • Salty foods (french fries and potato chips)
  • Processed meats

Finally, he mentioned that evidence suggests that high intake of the abovementioned foods may increase brain fructose levels, initiating a foraging response, followed by persistent “hyperactive foraging”, then neuron loss and death.

To know more, watch the full webinar

Be sure to check the recording of this webinar by visiting the HealthyLongevity.guide, where you can find much more information you can utilize to improve the longevity of your clients.

Don’t miss this book by Dr. Richard Johnson

In the marketplace section, you can find Dr. Johnson's publication ‘Nature Wants Us to Be Fat: The Surprising Science Behind Why We Gain Weight and How We Can Prevent—and Reverse—It’.

What’s next?

Stay tuned for our next webinar with Natasa Billeci on November 10, 9 AM PT. The upcoming webinar will cover the topic of “Reproductive Longevity: The Key to Women's Healthspan”.

Some useful sources

 

 

Article reviewed by
Dr. Ana Baroni MD. Ph.D.
SCIENTIFIC & MEDICAL ADVISOR
Quality Garant
Close

Dr. Ana Baroni MD. Ph.D.

Scientific & Medical Advisor
Quality Garant

Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.

DISCOVER
HealthyLongevity.guide
4.6 / 5
Professional science-based education
250+ Articles, video lectures, webinars
Community of 1000+ verified professionals
Sign Up

Read the latest articles

News
Disease

Prostaglandin E2 potentially increases susceptibility to influenza A infection in the elderly

November 30, 2022

A new study tested whether age-related elevation in Prostaglandin E2 is a driver that impairs host defense against influenza.

Ehab Naim, MBA.
Article
Lifestyle
Prevention

Future healthy longevity starts at conception

November 29, 2022

The habits we develop as children significantly impact lifespan and healthspan in adulthood. Dietary choices, exercise, or for example daily screen time can lead to lasting changes in the organism.

Agnieszka Szmitkowska, Ph.D.
News
Body

Good oral health keeps the body stronger for longer

November 25, 2022

Current research on older adults suggests a possible link between oral and physical health, such as muscle strength, where poor oral health leads to adverse changes in musculoskeletal health.

Agnieszka Szmitkowska, Ph.D.
Article
Longevity
Medicine

Nutrient sensing and its role in aging

November 23, 2022

Nutrient sensing is one of the hallmarks of aging. Four key nutrient sensing mechanisms are: insulin signaling, mTOR, AMPK, and sirtuins.

Olena Mokshyna, PhD.
News
Lifestyle

Tai Chi Quan could improve several aspects of neurodegenerative disorders

November 23, 2022

Tai Chi has a lot of proven health benefits. Wang et al. analyzed 58 different studies to evalute what exactly is its effect on diseases, such as Parkinson’s or multiple sclerosis.

Ehab Naim, MBA.
News
Aging

Essential amino acid L-threonine prolongs healthspan thanks to ferritin

November 22, 2022

A study evaluated whether the metabolites whose concentrations are increased during caloric restriction reduce the age-related decline.

Agnieszka Szmitkowska, Ph.D.
News
Disease
Medicine

Acute aortic dissection can be caused by DNA methylation

November 17, 2022

In a recent study, DNA methylation was proven to be a risk factor for the acute aortic dissection.

Agnieszka Szmitkowska, Ph.D.
Article
Lifestyle
Longevity
Nutrition

The MIND Diet Promotes the Longevity of Cognitive Health

November 18, 2022

The MIND diet classifies 15 dietary components based on their effect on the brain, and recommends how many servings we should eat.

Jiří Kaloč
News
Aging
Longevity

Exploring microbiome diversity as a contributor to frailty

November 15, 2022

To evaluate the effect of microbiota diversity on health, Rashidah et al. reviewed microbiota composition, intestinal permeability, and inflammatory biomarkers in older adults.

Ehab Naim, MBA.
Article
Body
Supplements

Alpha-ketoglutarate in human trials against diseases and aging

November 11, 2022

Alpha-ketoglutarate (AKG) is a versatile endogenous compound that serves multiple functions in the body. It supports longevity thanks to its beneficial effects on cardiac, bone and muscle health.

Olena Mokshyna, PhD.
News
Aging
Disease
Longevity

Small extracellular vesicles from stem cells improve healthspan and lifespan in old mice

November 10, 2022

A recent study suggests that small extracellular vesicles could prevent age-related conditions and promote tissue regeneration.

Agnieszka Szmitkowska, Ph.D.
Article
Body
Lifestyle

How Much Exercise and What Type Is Needed to Live Longer?

November 6, 2022

Well planned exercise routine leads to prolonged healthspan. Several studies examined what is the ideal amount of exercise per week, or how many steps we should walk every day.

Jiří Kaloč
News
Prevention

Sleep duration during midlife and old age influences the risk of chronic diseases

November 4, 2022

A study examined the link between sleep duration and multimorbidity, and assessed whether sleep duration at the age of 50 influences the natural course of chronic diseases.

Ehab Naim, MBA.
Article
Disease
Lifestyle

Hypertension: How does high blood pressure influence the healthspan and lifespan?

November 3, 2022

1.2 billion people are affected by hypertension. Luckily, research shows that people can influence their blood pressure through simple changes in their diet and lifestyle.

Ehab Naim, MBA.
News
Aging

Inflammaging: How aging modulates the immune system

November 1, 2022

A study evaluated what is the impact of inflammaging on the adaptive and innate immune system.

Ehab Naim, MBA.
Article
Diagnostics
Aging

Epigenetic clocks: monitoring aging through DNA methylation

October 31, 2022

Epigenetic clocks provide one of the most accurate and easy ways to assess the real age of a human body. They also demonstrate encouraging results in the area of anti-aging intervention assessment.

Olena Mokshyna, PhD.
No items found.