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Cellular senescence: role in cancer and aging (Webinar with Eleanor Sheekey recording)

Video
June 3, 2022
By
Ehab Naim, MBA.

Cellular senescence is one of the nine aging hallmarks with the negative impact but also with good aspects, including wound healing, fibrotic tissue resolution, limb patterning...

Cellular senescence: role in cancer and aging (Webinar with Eleanor Sheekey recording)

The HealthyLongevity.guide is proud to announce another successful webinar. In this webinar, our speaker Eleanor Sheekey, a Ph.D. scholar, and scientist, covered some interesting points about cellular senescence and its influence on longevity. The webinar was hosted by HealthyLongevity.guide content creators Olena Mokshyna, Ph.D., and Ehab Naim, MBA.

At the beginning of the webinar, Eleanor explained the process of cellular turnover in solid organs. The initial process is replacing damaged or aged cells, which usually undergo apoptosis. Then, stem cells divide and generate a new cell that replaces the one removed by apoptosis and clearance mechanisms. Then, Eleanor provided historical background about cellular senescence and mentioned Leonard Hayflick, who first reported the process. Afterward, she explained the cause behind cellular senescence – telomere shortening. She highlighted that telomeres are structures that have a protective role and cap the ends of chromosomes. Eleanor explained the potential processes that cause senescence, like oncogene activation, replicative stress, DNA damage, and oxidative stress. Then, she discussed the features of senescent cells and revealed how they develop and the value of clearing these cells.

During the webinar, she explained the good aspects of senescence, including wound healing, fibrotic tissue resolution, limb patterning, and others. Also, she highlighted the value of the said process in protection against cancer as a tumor suppression mechanism. She revealed that cellular senescence is one of the nine aging hallmarks. Then, she went on to discuss the negative impact of this process. She explained some results from preclinical research highlighting how the removal of senescent cells improves physical function in old mice. Moreover, she mentioned how accumulating these cells could potentially cause glaucoma, neurodegenerative disorders, type 2 diabetes, and many other conditions.

Afterward, Eleanor discussed a class of therapeutics called senolytics. She revealed that this class of medications selectively kills senescent cells. Eleanor provided examples of senolytic molecules like quercetin and dasatinib and highlighted preclinical research involving these compounds. She also discussed some foods containing naturally occurring senolytics. Afterward, Eleanor provided examples of clinical trials investigating some of the aforementioned senolytic agents and shared insights about what we know and what needs to be explored about senescence.   

Be sure to check the recording of this webinar by visiting the HealthyLongevity.guide, where you can find much more information you can utilize to improve the longevity of your clients. Stay tuned for our next webinar with Dr. Thet Lewin on June 30th, 9 AM PT. The upcoming webinar will discuss precision nutrition, nutrient-sensing, and the role of the circadian rhythm.

Some useful resources:

The original article discussing the nine hallmarks of aging:

Mechanisms of cellular senescence: 

  • https://www.frontiersin.org/articles/10.3389/fcell.2021.645593/full

Senolytics:

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/

Cellular senescence: role in cancer and aging (Webinar with Eleanor Sheekey recording)

The HealthyLongevity.guide is proud to announce another successful webinar. In this webinar, our speaker Eleanor Sheekey, a Ph.D. scholar, and scientist, covered some interesting points about cellular senescence and its influence on longevity. The webinar was hosted by HealthyLongevity.guide content creators Olena Mokshyna, Ph.D., and Ehab Naim, MBA.

At the beginning of the webinar, Eleanor explained the process of cellular turnover in solid organs. The initial process is replacing damaged or aged cells, which usually undergo apoptosis. Then, stem cells divide and generate a new cell that replaces the one removed by apoptosis and clearance mechanisms. Then, Eleanor provided historical background about cellular senescence and mentioned Leonard Hayflick, who first reported the process. Afterward, she explained the cause behind cellular senescence – telomere shortening. She highlighted that telomeres are structures that have a protective role and cap the ends of chromosomes. Eleanor explained the potential processes that cause senescence, like oncogene activation, replicative stress, DNA damage, and oxidative stress. Then, she discussed the features of senescent cells and revealed how they develop and the value of clearing these cells.

During the webinar, she explained the good aspects of senescence, including wound healing, fibrotic tissue resolution, limb patterning, and others. Also, she highlighted the value of the said process in protection against cancer as a tumor suppression mechanism. She revealed that cellular senescence is one of the nine aging hallmarks. Then, she went on to discuss the negative impact of this process. She explained some results from preclinical research highlighting how the removal of senescent cells improves physical function in old mice. Moreover, she mentioned how accumulating these cells could potentially cause glaucoma, neurodegenerative disorders, type 2 diabetes, and many other conditions.

Afterward, Eleanor discussed a class of therapeutics called senolytics. She revealed that this class of medications selectively kills senescent cells. Eleanor provided examples of senolytic molecules like quercetin and dasatinib and highlighted preclinical research involving these compounds. She also discussed some foods containing naturally occurring senolytics. Afterward, Eleanor provided examples of clinical trials investigating some of the aforementioned senolytic agents and shared insights about what we know and what needs to be explored about senescence.   

Be sure to check the recording of this webinar by visiting the HealthyLongevity.guide, where you can find much more information you can utilize to improve the longevity of your clients. Stay tuned for our next webinar with Dr. Thet Lewin on June 30th, 9 AM PT. The upcoming webinar will discuss precision nutrition, nutrient-sensing, and the role of the circadian rhythm.

Some useful resources:

The original article discussing the nine hallmarks of aging:

Mechanisms of cellular senescence: 

  • https://www.frontiersin.org/articles/10.3389/fcell.2021.645593/full

Senolytics:

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/

Article reviewed by
Dr. Ana Baroni MD. Ph.D.
SCIENTIFIC & MEDICAL ADVISOR
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Dr. Ana Baroni MD. Ph.D.

Scientific & Medical Advisor
Quality Garant

Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.

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